Primary antiphospholipid syndrome and panhypopituitarism: a unique presentation

Lymphocytic hypophysitis (LH) has been describedpreviously in systemic lupus erythematosus (1.3%),Sjögren’s syndrome (0.8%). Lymphocytic hypophysitis(LH) is rarely associated with rheumatic diseases, althoughthree cases of pituitary disease associated withantiphospholipid syndrome (APS) have been des -cribed. Here, we report a possible association betweenAPS and LH for the first time. A 34-yr-old woman withprimary APS presented with polyuria, polydipsia, hypernatremiaand impaired vision. Her hormone profilewas compatible with panhypopituitarism, and sellarmagnetic resonance imaging (MRI) depicted a normalpituitary gland with a thickened and displaced stalkand infundibulum portion. Hormone replacement wasstarted, and the patient experienced a good clinical evolution.