Association of body mass index with Juvenile Idiopathic Arthritis disease activity: a Portuguese and Brazilian collaborative analysis
97). Disease activity was assessed by Juvenile Arthritis Disease Activity Score (JADAS-27). Uni- and multivariate analyses were performed. Results: A total of 275 patients were included. The prevalence of underweight, normal weight, overweight and obesity was 6.9%, 67.3%, 15.3% and 10.5%, respectively. Underweight patients had significantly higher number of active joints (p <0.001), patient’s/parent’s global assessment of disease activity (PGA) (p=0.020), physician’s global assessment of disease activity (PhGA) (p <0.001), erythrocyte sedimentation rate (ESR) (p=0.032) and overall higher JADAS-27 (p <0.001), compared to patients with normal weight, overweight and obesity. In the multivariate regression, underweight persisted significantly associated with higher disease activity, compared to normal weight (B=-9.430, p <0.001), overweight (B=-9.295, p=0.001) and obesity (B=-9.120, p=0.001), when adjusted for age, gender, country, ethnicity, JIA category and therapies used. The diagnosis of RF- (B=3.653, p=0.006) or RF+ polyarticular JIA (B=5.287, p=0.024), the absence of DMARD therapy (B=5.542, p <0.001) and the use of oral GC (B=4.984, p=0.002) were also associated with higher JADAS-27. Conclusion: We found an independent association between underweight and higher disease activity in patients with JIA. Further studies are needed to understand the underlying mechanisms of this association.
Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon. CEDOC, NOVA Medical School, Lisbon. Rheumatology Department, Hospital Central do Funchal, Madeira.
Ana Filipa Mourão
Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon. CEDOC, NOVA Medical School, Lisbon.
Filipa Oliveira-Ramos
Rheumatology and Metabolic Bone Diseases, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon. Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
Raquel Campanilho-Marques
Rheumatology and Metabolic Bone Diseases, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon. Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
Paula Estanqueiro
Pediatric Rheumatology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra
Manuel Salgado
Pediatric Rheumatology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra
Margarida Guedes
Unidade de Imunologia Clínica, Centro Hospitalar Universitário do Porto, Porto
Daniela Piotto
Pediatric Rheumatology Unit, Universidade Federal de São Paulo, Brazil.
Nadia Emi Aikawa
Universidade de São Paulo, Brazil
José Melo Gomes
Instituto Português de Reumatologia, Lisbon. Clínica Dr. Melo Gomes, Lisbon.
Marta Cabral
Pediatrics, Hospital Prof. Doutor Fernando Fonseca, Amadora.
Marta Conde
Pediatric Rheumatology Unit, Hospital Dona Estefânia, Centro Hospitalar de Lisboa Central, Lisbon.
Ricardo Figueira
Rheumatology Department, Hospital Central do Funchal, Madeira.
Maria José Santos
Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa; Rheumatology Department, Hospital Garcia de Orta, Almada.
João Eurico Fonseca
Rheumatology and Metabolic Bone Diseases, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon. Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
Maria Teresa Terreri
Pediatric Rheumatology Unit, Universidade Federal de São Paulo, Brazil.
Helena Canhão
Comprehensive Health Research Center (CHRC), NOVA Medical School, Lisbon. CEDOC, EpiDoC Unit, NOVA Medical School, Lisbon.
